Plenity is a New FDA Cleared Supplement for Weight Loss

Plenity is an FDA cleared supplement for weight management made from naturally derived cellulose and citric acid. Three capsules are taken twice a day, 20 minutes before lunch and dinner with 16 ounces of water. The capsules swell up to fill your stomach to make you feel full. The ingredients are not absorbed systemically and are eliminated from the body in the same manner as food. The average weight loss with Plenity is about 10% (about 22 pounds).

Plenity is only available by prescription. Insurance does not cover Plenity, and it costs about $100 per month, which is comparable to other weight loss medications such as Qsymia or Contrave.

The concept behind Plenity is different than other weight loss medications such as semaglutide that work in the appetite center of the brain. Plenity physically fills the stomach, and when taken right before a meal, there is very little room left in the stomach. The concept is like a temporary gastric balloon taken before each meal. A regular gastric balloon stays in the stomach for 4-6 months. In my experience, the long-term results from gastric balloons have not been encouraging and there can be quite a few complications. The hope is that Plenity is a safer and more effective alternative.

Remember, Plenity like other medications are not a magic bullet but simply a tool to help you sustain common sense lifestyle changes. There is no perfect medication for obesity. A medication that may work for a family member or a friend may not be the ideal medication for you. Treating obesity can be complicated so it is best to work with a knowledgeable health care professional who is dedicated to working with you over the long term.

Currently, weight loss medications approved by the Food and Drug Administration (FDA) for weight loss.

phentermine (Adipex-P®, Lomaira®)*

phendimetrazine (Bontril®)*

benzphetamine (Regimex®, Didrex®)*

orlistat (Xenical®, alli®)†

phentermine and topiramate ER (Qsymia®)†


naltrexone HCl and bupropion HCl (CONTRAVE®)†

liraglutide injection (Saxenda®)†

semaglutide injection (wegovy®)†

*Approved for short term use
†Approved for long term (chronic) use

If you’d like to learn more about permanent weight loss, please feel free to call us or schedule an appointment with Dr. Isaacs using the online booking tool on this website.

Scott Isaacs, MD Endocrinologist and Weight Loss Specialist

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