What Are Anti-Obesity Medications and How Do They Work?

The magic pill has been the Holy Grail since oral medications were first invented. Imagine taking one pill and waking up the next day completely cured of whatever ails you. While many pills do, in fact, perform small feats of magic in helping us manage medical issues, the overnight sensation of a magic pill is still not here. And this is especially true when it comes to managing weight issues.

But that isn’t to say that medications can’t help in the battle against obesity. Here at Atlanta Endocrine Associates, we’ve successfully helped many of our patients in Atlanta, Georgia, lose weight and keep it off with the help of anti-obesity medications.

Here’s a look at these anti-obesity medications and how they work.

The problem

Obesity, or adiposity, affects an incredible 650-700 million people worldwide, including 93 million in the United States, and those numbers continue to increase each year. To say that obesity is an epidemic would not be overstating matters. Unfortunately, it’s an epidemic that has life-or-death consequences, thanks to the health complications that are brought on by obesity, which is why the medical world has been scrambling for years to come up with a solution.

The biggest problem lies in the fact that long-term weight loss is extremely difficult, even with the proper diet and exercise. While you may benefit from a short-term loss in weight, your hormones often end up working against you, increasing your appetite and lowering your metabolism. And willpower alone isn’t usually strong enough to face off against these biological impulses to eat more.

The solution

Since your hormones control your appetite and your metabolism, many researchers have focused on ways to override your hormones, as well as change the way your body processes fat.

The resulting medications aren’t magic, so far, but they’ve helped many people take the weight off when nothing else worked. Medications that have been approved by the FDA, include:

The short view

For short-term weight loss, either to kick you off on a broader weight loss plan or because you need to lose weight quickly for a looming medical issue, phentermine, phendimetrazine, and benzphetamine are the most effective. These medications contain mild stimulants that decrease your appetite.

We don’t recommend these types of appetite suppressants for long-term use, since your body builds up a tolerance toward them after a few months. You also shouldn’t use these medications if you have heart or other medical issues that won’t tolerate the stimulants well.

For most patients, we prescribe these medications for periods of up to 12 weeks, or 24 weeks if you’re taking the pills every other day.

The long view

For patients who want a long, controlled approach to weight loss, the other drugs on the list above have helped patients lose an average of 5-15% of their body fat in 6-12 months. And here’s, briefly, how each works:

Each of these medication protocols are designed and tested for long-term use.

Not for everyone

While we saved this point for last, it’s perhaps the most important one. Anti-obesity medications are only available to those who are classified as obese with a body mass index (BMI) of 30 or higher or people with a BMI above 27 and at least one serious health complication because of their weight.

In addition to these restrictions, we don’t just hand you a prescription and call it a day. We still have a lot of work to do in changing your nutrition and exercise habits, and you need to still keep your caloric intake to under 1,200-1,400 every day.

Rest assured, we’re here to help and provide you with the tools necessary for appreciable and healthy weight loss.

If you’d like to learn more about anti-obesity medications, please feel free to call us or schedule an appointment with Dr. Isaacs using the online booking tool on this website.

Scott Isaacs, MD Endocrinologist and Weight Loss Specialist

You Might Also Enjoy...

Addressing weight regain after bariatric surgery

The average weight loss for patients who undergo bariatric surgery is around 33% of initial body weight compared to an average weight loss of 10% with anti-obesity medications and 3-5% with a low-calorie diet and lifestyle modification.

Long-term hormonal and metabolic adaptations to weight loss

Weight recidivism occurs because reducing body weight triggers adaptive mechanisms that drive weight regain. Body weight is tightly regulated by hormones from the GI tract, pancreas, and adipose tissue that act primarily in the hypothalamus to regulate foo

What You Need to Know About Fatty Liver

Fatty liver or nonalcoholic fatty liver disease (NAFLD) is a disorder in which too much fat builds up in the liver. Nonalcoholic steatohepatitis (NASH) occurs when that extra fat causes inflammation and scarring of the liver.

If It's Not My Thyroid Then What Is It?

Fatigue, weight gain, mood swings, poor concentration, memory issues, sweating, heart palpitations – your internet search says these are all symptoms of thyroid disease…but what happens when thyroid blood tests are actually normal?